Recently, foreign news reported that the US Food and Drug Administration (FDA), because the research published by Dr. Conan of Yale University in the New England Journal of Medicine confirmed that PPA use in weight loss, even under normal dosage, regardless of short-term or long-term effect, will increase the probability of female stroke by 16.58 times, and the risk of female stroke for the first time is up to 3.13 times. In terms of weight loss, the average use of PPA by both sexes still has a risk of 15.92 times as high as hemorrhagic stroke. Therefore, FDA banned the sale of PPA. In this study, 702 patients with cerebral hemorrhage were collected from 43 hospitals in the United States, and 1376 control patients were studied. This study concluded that the use of PPA is indeed a risk factor for women in terms of weight loss, and if it is used in the treatment of colds, it is a possible risk factor. After the assessment by the National Health Administration, it is believed that the use of PPA in China is small, and PPA has not been banned in Europe and Japan, so China will continue to use PPA, but limit the use of large doses. PPA manufacturer

2、 Working principle of PPA

PPA is actually the abbreviation of Phynylpropanolamine, which is a drug similar to ephedrine and amphetamine in structure and function. It is a sympathetic nerve analogue and can cause vasoconstrictor. Therefore, some patients will have the occurrence of malignant hyperpyrexia. At present, PPA is widely used as a therapeutic agent for cold nasal congestion. PPA is stored in many well-known long-term or short-term cold capsules or syrups on the market. In addition, a large dose of PPA is also widely used as a weight loss drug, which is one of the few legally used weight loss drugs. Therefore, PPA is also a common drug of legal abuse in China. Often introduced by the market and beauty salons, it is widely used by many women as a weight loss drug.

3、 Hazardous side effects of PPA:

Side effects of PPA often occur for the first time or multiple users, which are not related to the dose size, duration of action, and are often unexpected, and often vary with individual constitution. The serious side effect of zui is hemorrhagic stroke, which is life threatening. Other possible side effects are:

Cardiovascular: arrhythmia, hypotension, shock, too fast or too slow heartbeat, transient hypertension.

Central nervous system: anxiety, inability to rest, restlessness, headache, dizziness, jitter, insomnia, mental disorders, generalized convulsions, weakness, etc.

Gastrointestinal system: nausea, vomiting, anorexia, dry mouth, etc.

Others, such as dysuria and dyspnea, may occur.

4、 High risk patients using PPA

Therefore, for patients with high risk of PPA, such as hypertension, hyperthyroidism, diabetes, cardiovascular disease, cardiac ischemia, narrow heart disease, glaucoma and prostate hypertrophy. If you are a female patient with the above dangerous symptoms, you should be very careful or not give it. Of course, it should not be given to patients with special constitution and allergic constitution or those who have used it before and have serious reactions.

5、 Excessive poisoning of PPA

If PPA is used excessively, it will have the following toxic effects:

Cardiovascular: arrhythmia and cardiac paralysis, hypotension, shock, chest pain and myocardial infarction, malignant hypertension and cerebral hemorrhage.

Central nervous system: anxiety, restlessness, headache, dizziness, jitter, mental disorder, generalized convulsions, consciousness coma and confusion, hypertensive encephalopathy, etc.

Gastrointestinal system: nausea, vomiting, liver disease, etc.

Others, such as hyperthermia, myolysis, acute renal failure, dyspnea and respiratory distress, and death, may occur.

There is no special antidote for PPA poisoning, and only supportive and symptomatic treatment such as gastric lavage, active carbon and cathartic can be given. It has been reported that blood lavage may be effective, which needs further research to confirm.